56 Day Glandular Ulcer Bundle

Equine Glandular Gastric Disease (EGGD)

Studies indicate omeprazole or sucralfate as a sole treatment is not as effective as a combination of the two, as their modes of action are complimentary.

Recommended to administer both omeprazole and sucralfate to treat glandular ulcers.

To achieve the best results when treating glandular ulceration, administer omeprazole in the morning at least an hour before training or main morning feed. Give sucralfate at least twice a day with a small feed (handful of chaff) at least 30minutes apart from all other medications and supplements.

Generally, a horse's stomach is not so full in the morning.

Omeprazole is a one time dose per day, being effective for 24hours.

Sucralfate is a multiple daily dose medication - give at least twice-a-day. Effective for 6 to 8hours. Length of administration depends on the condition, severity and type of ulcer being treated.

The following dosage example is based on a horse weighing 430kg (950lb) as a loading or active treatment or preventative, maintenance dose.

Regime:Treatment

• Loading or active treatment dose: example for horse weighing 430kg (950lb)
  • Week 1 - 6: Omeprazole (AbPrazole) - 2 x sachets, once per day
  • Week 7 - 8: Omeprazole (AbPrazole) - as required
  • Week 1 - 3: Sucralfate (AbSucralfate)- 3 x sachets, two times per day
  • Week 4 - 8: Sucralfate (AbSucralfate - 2 x sachets, two times per day

• Maintenance or preventative dose:
  • Ongoing: Sucralfate 1 x sachet, two times per day.

This Glandular Ulcer Bundle includes Omeprazole x 6 weeks and Sucralfate x 8 weeks

AbSucralfate Granules

• Top dress granules to a handful of dry or moist chaff
• Add to corn syrup, molasses or a treat
• Mix into a paste and smear onto apples or carrots
• Mix with water and administer via oral syringe
• Most effective when fed at least 30 minutes apart from other medication and supplements.
• Try to feed when horses stomach is least likely to be at its fullest.

AbPrazole or AbPrazole Plus  Granules

• Top dress dry granules onto dry or moist feed. A small amount of oil, corn syrup or molasses can be added to the feed mix.
• Add to apple sauce and spread onto a treat such as an apple or carrot.
• DO NOT expose AbPrazole granules to water or the enteric coating will be damaged. 

Massive overdosage is required to cause problems in other species but the toxic dosage in horses is uncertain. Rats have tolerated oral doses no greater than 40mg/kg (this would be equivalent to ten times of 100% product fed to a horse at one time).

Omeprazole appears to be a safe drug with low associated problems. It is contraindicated in horses hypersensitive to it. Omeprazole may decrease the hepatic clearance of some medications. Omeprazole's safety during pregnancy has not been established.

Omeprazole, like other PPI's, is well tolerated. Nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention occur infrequently.

Omeprazole appears to be very well tolerated in horses. There may be a possibility of Gastro Intestinal (GI) distress (anorexia, colic, flatulence, diarrhea).

• Do not treat horses intended for human consumption.
• Keep out of reach of children.
• Veterinary use only.

• Store in a cool dry atmosphere away from extreme heat.
• Store/Transport at and 20º to 30ºC ( 68º to 86ºF)

Watch how horse owners feed granules

Omeprazole granules 

Sucralfate granules

Administering Sucralfate as an ulcer prevention